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Company History

December 2008

Acquisition of Protherics PLC

November 2008

BGC945, a targeted developmental cancer treatment, is licensed to Onyx Pharmaceuticals, Inc

June 2008

Protez Pharmaceuticals, founded in 2003 by BTG and its management team to discover and develop novel antibiotics, is acquired by Novartis

October 2007

BTG’s licensee Tolerx, Inc forms a collaboration with GlaxoSmithKline to develop TRX4 for a range of auto-immune disorders

September 2007

Genzyme corporation, BTG’s licensee, starts Phase III trials of Campath® in multiple sclerosis

September 2007

IP for CoVaccine HT™ licensed to Nobilon, a division of Schering Plough, for use in its flu vaccines

December 2006

Positive results from the EU Phase III trial of Varisolve®, under development as a treatment for varicose veins, published in Phlebology

February 2006

BTG licenses novel compounds for Alzheimer’s Disease to Senexis Limited and co-invests in Senexis alongside the Wellcome Trust

December 2005

Development and commercialisation agreement with AstraZeneca for CytoFab™, under development to treat severe sepsis

May 2005

BTG announces plans to divest physical sciences interests and to focus solely on life sciences

2003

Nobel Prize for Medicine awarded to inventor of MRI, a technology first licensed by BTG in the 1980s

2002

US launch of DigiFab™, a treatment for the toxic effects of over dosage with the heart drug digoxin

2001

US approval of Campath® and EU approval of MabCampath® for chronic lymphocytic leukaemia

2001

US launch of CroFab™, the first new rattlesnake anti-venom on the US market in 50 years

1999

BTG forms Provensis Ltd to develop and commercialise Varisolve®, a novel treatment for varicose veins

1999

Protherics PLC formed from the merger of Proteus International plc and Therapeutic Antibodies Inc.

1997

BeneFIX® recombinant Factor IX treatment for haemophilia B launched in the US

1995

BTG plc is listed on the London Stock Exchange

1992

BTG is privatised

1981

BTG is formed from the merger of the National Research & Development Council and the National Enterprise Board

1970s

Patenting/development of: cholesterol assay tests; MRI; Oxford three-part knee

1960s

Patenting/development of: continuously variable transmission; cephalosporin antibiotics; pyrethrin insecticides

1950s

Patenting of interferon

1948

National Research Development Corporation founded by UK government to commercialise publicly funded research

Note: Milestones in italics are Protherics milestones prior to the merger with BTG